Coronaviruses roadmap:
Diagnostic Tests
Roadmap for the development of diagnostic tests for coronaviruses
Download 202410 Draft Coronavirus Diagnostic Development_FinalB
Cell-mediated immunity
Cell-mediated immunity
Research Question
- Can T-cell immunity be used as a diagnostic tool for detection and surveillance for animals?
Research Gaps and Challenges
- Tests are time consuming and expensive
- Unclear understanding of cell-mediated immunity in some species the basic immunology is not well characterised
- High species-dependence
Solution Routes
- Development of relatively rapid T-cell assays
- In highly important cases, T-cell can be used in high-value samples
Dependencies
- Availability of new and rapid platform
- Specific knowledge in certain animal species
State Of the Art
T-cells, especially memory T-cells, play a crucial role in long-term immunity against SARS-CoV-2
Projects
What activities are planned or underway?
Differential susceptibility of SARS-CoV-2 in animals : Evidence of ACE2 host receptor distribution in companion animals, livestock and wildlife by immunohistochemical characterisation
Planned Completion date 26/07/2021
Participating Country(s):
Netherlands
Veterinary Biocontained facility Network for excellence in animal infectiology research and experimentation
Planned Completion date 28/02/2023
Participating Country(s):
Europe