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Cell mediated immunity

Cell-mediated immunity

Research Question

  • Diagnose the presence and valence of cell-mediated immunity against AIV

Research Gaps and Challenges

  • High laboratory specialization and technical skills of staff required
  • Limited understanding of variation of mechanisms between species and viral strains
  • Need for specific equipment to measure immune cells (I.e.: FACS, etc)
  • Variable genetic backgrounds of host (I.e.: commercial breeds versus backyard stocks)

Solution Routes

  • Develop technically undemanding and cost-effective tools to define (parts) of CMI
  • Role of cell-mediated immunity (CMI) in individual animal recovery and outbreak outcomes
  • Tools to define immune cell populations in avian species
  • Test to predict cell mediated levels and correlate with vaccine protection

Dependencies

  • Basic data on the development of cellular immune effectors in various avian species
  • Research facilities that can hold animals for a long period of time (months) to determine if CMI is protective against heterologous challenge

Projects

What activities are planned or underway?

Protect wildlife from livestock diseases.

Planned Completion date 07/10/2022

Participating Country(s):

NetherlandsIconNetherlands

Impact of host age on viral and bacterial communities in a waterbird population.

Planned Completion date 01/11/2022

Participating Country(s):

NetherlandsIconNetherlands