African Swine Fever roadmap:
Vaccines
Roadmap for the development of a candidate vaccine for ASF
Download ASF Vaccine Roadmap15
Host responses to natural infection
Dependencies
Next steps
Host responses to natural infection
Research Question
- ASF virus cause acute – chronic infection reflecting the virulence of the virus strain or the host (genetics). Understanding the different responses could shed light on the protective mechanisms and virulence factors
Research Gaps and Challenges
- Perform studies in the different hosts
- Apply transcriptomic approach (in wild boars)
Solution Routes
- Comparative studies of the pathogenic mechanisms of acute and chronic forms induced by high and low virulence ASFV isolates respectively
- Molecular differences in the pathogenesis process induced by virus with different degree of virulence
- Comparative studies of wild type and mutants where specific genes have been deleted
- Apply the interactomic approach for ASFV infection
- The role of specific genomic determinant(s) in disease outcome
Dependencies
- Improve understanding of the host pathogen interaction including persistence versus clearance
Projects
What activities are planned or underway?
The impact of temperature on transmission of African swine fever in contaminated livestock vehicles
Planned Completion date 01/01/2023
Source Countries:
Netherlands
A Multi-Laboratory Comparison of Methods for Detection and Quantification of African Swine Fever Virus.
Planned Completion date 07/03/2022
Source Countries:
Netherlands