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Host responses to natural infection

Host responses to natural infection

Research Question

  • Better understanding of host response so that vaccines can be designed to address the challenges for multiple target species

Research Gaps and Challenges

  • Role of prior infections to aid innate immune response or affect vaccines response e.g. subsequent vaccine uptake
  • Effect of co – infection with different viruses and bacteria on AIV
    transmission and pathogenesis
  • Role of pre – exposure to AIV on subsequent AIV infections
  • Impact of NDV infection on AIV replication
  • Knowledge on the duration of immunity of LP and HP in wild birds
  • Some vaccines do not produce measurable correlates of protection
  • Identify what is the main immune responses generated and against what
  • Inhibition of immunity by other co- vaccines or co- infection (e.g. role of immunosuppressive diseases)
  • What determines antigenic drift?

Solution Routes

  • Immune response to IAV vaccine in young pigs co-infected with immunosuppressive viruses (PCV2 and/or PRRSV) lack of knowledge in horses too
  • Characterization of the post-infectious adaptive immune response that determines protection from reinfection with homologous or heterologous strains
  • Vaccine matching / role of intermediary immunity in protection and virus mutation
  • Role of prior infections to aid innate immune response
  • Dysregulation of the innate responses (or the lack of it ) in target species?
  • Investigate immune mechanisms that impact the immunopathology

Dependencies

  • Strategies to improve vaccine responses in ovo or in young animals, especially in the presence of maternal antibody (issue in both poultry and swine) (see control strategies roadmap)
  • Develop strategies or technologies to induce earlier vaccine protection in ovo and in young poultry , e.g. rHVT (see control strategies roadmap)

Projects

What activities are planned or underway?

Protect wildlife from livestock diseases.

Planned Completion date 07/10/2022

Participating Country(s):

NetherlandsIconNetherlands

Dynamics of sustainability in integrated agriculture : aquaculture systems in the Mekong Delta

Planned Completion date 21/10/2024

Participating Country(s):

NetherlandsIconNetherlands