Influenza roadmap:
Vaccines
Roadmap for the development of candidate vaccines for influenza
Download Influenza-vaccine-development-roadmap15
Host responses to natural infection
Dependencies
Next steps
Host responses to natural infection
Research Question
- Better understanding of host response so that vaccines can be designed to address the challenges for multiple target species
Research Gaps and Challenges
- Role of prior infections to aid innate immune response or affect vaccines response e.g. subsequent vaccine uptake
- Effect of co – infection with different viruses and bacteria on AIV
transmission and pathogenesis - Role of pre – exposure to AIV on subsequent AIV infections
- Impact of NDV infection on AIV replication
- Knowledge on the duration of immunity of LP and HP in wild birds
- Some vaccines do not produce measurable correlates of protection
- Identify what is the main immune responses generated and against what
- Inhibition of immunity by other co- vaccines or co- infection (e.g. role of immunosuppressive diseases)
- What determines antigenic drift?
Solution Routes
- Immune response to IAV vaccine in young pigs co-infected with immunosuppressive viruses (PCV2 and/or PRRSV) lack of knowledge in horses too
- Characterization of the post-infectious adaptive immune response that determines protection from reinfection with homologous or heterologous strains
- Vaccine matching / role of intermediary immunity in protection and virus mutation
- Role of prior infections to aid innate immune response
- Dysregulation of the innate responses (or the lack of it ) in target species?
- Investigate immune mechanisms that impact the immunopathology
Dependencies
- Strategies to improve vaccine responses in ovo or in young animals, especially in the presence of maternal antibody (issue in both poultry and swine) (see control strategies roadmap)
- Develop strategies or technologies to induce earlier vaccine protection in ovo and in young poultry , e.g. rHVT (see control strategies roadmap)
Projects
What activities are planned or underway?
Protect wildlife from livestock diseases.
Planned Completion date 07/10/2022
Participating Country(s):
Netherlands
Dynamics of sustainability in integrated agriculture : aquaculture systems in the Mekong Delta
Planned Completion date 21/10/2024
Participating Country(s):
Netherlands