Home ‹ Porcine Reproductive & Respiratory Syndrome ‹ [Identity of immunomodulators] To establish the identity of the immunomodulatory factors/stealth mechanisms in PRRSV
Porcine Reproductive & Respiratory Syndrome roadmap:
Vaccines

Roadmap for development of a candidate vaccine for PRRSV

Download PRRSV Vaccine Roadmap

14

Identity of immunomodulators

visit roadmap

Dependencies

Next steps

To establish the identity of the immunomodulatory factors/stealth mechanisms in PRRSV

Research Question

  • PRRSV attempts to modulate the host’s immune responses so that it can survive and replicate
  • The early Ab response isn’t protective and VN-Abs don’t appear until 6 weeks into infection
  • Identifying and removal of the factors contributing to the virus stealth mechanisms could contribute to the generation of improved attenuated vaccine candidates

Solution Routes

  • Generation of a range of knock-out viruses where the genes for various immunomodulatory factors or other stealth mechanisms have been removed and their use in experimental infections
  • Modulation of innate immune responses

Dependencies

  • Improved understanding of virus-macrophage interaction – viral and macrophage gene expression in different in vivo environments (macrophages from naïve and immune hosts)

Projects

What activities are planned or underway?

Immune responses induced by inactivated Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) vaccine in neonate pigs using different adjuvants

Planned Completion date 01/02/2021

Source Countries:

NetherlandsIconNetherlands

Modified live vaccine strains of porcine reproductive and respiratory syndrome virus cause immune system dysregulation similar to wild strains.

Planned Completion date 12/01/2024

Source Countries:

NetherlandsIconNetherlands