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Roadmap for the development of candidate vaccines for influenza

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Identity of mechanisms of protection

Identity of mechanisms of protection

Research Question

  • Understand host susceptibility and immune response in inter-and intra-host transmission

Research Gaps and Challenges

  • Increase knowledge on host factors in natural hosts associated with resistance or susceptibility to influenza infection and several hosts (e.g. cell receptors, intracellular enzymes, innate immunity, etc. )
  • Identify the contribution of the various arms of the immune response to protection – correlates of protection particularly in wild bird
  • Knowledge on immunity levels required for re-infection of same or variants

Solution Routes

  • Identification of B- and T-cell epitopes that provide best protection from inactivated and vectored vaccines
  • Better understanding of response to attenuated pathogens – very limited knowledge in avian species
  • Identification of conserved B- and T-cell epitopes within and between virus subtypes for targeting by vaccines
  • Role of unregulated cytokine expression in production of vaccine associated enhanced respiratory disease of swine
  • Immune correlates of vaccine-induced protection
  • More reliable in vitro assays that can measure correlate of protection

Dependencies

  • Development of rapid or reliable in vitro assays superior to HI /VN that also account for cellular and mucosal immune response and correlate with protection

Projects

What activities are planned or underway?

Protect wildlife from livestock diseases.

Planned Completion date 07/10/2022

Participating Country(s):

NetherlandsIconNetherlands

Dynamics of sustainability in integrated agriculture : aquaculture systems in the Mekong Delta

Planned Completion date 21/10/2024

Participating Country(s):

NetherlandsIconNetherlands