Influenza roadmap:
Vaccines
Roadmap for the development of candidate vaccines for influenza
Download Influenza-vaccine-development-roadmap16
Identity of mechanisms of protection
Dependencies
Next steps
Identity of mechanisms of protection
Research Question
- Understand host susceptibility and immune response in inter-and intra-host transmission
Research Gaps and Challenges
- Increase knowledge on host factors in natural hosts associated with resistance or susceptibility to influenza infection and several hosts (e.g. cell receptors, intracellular enzymes, innate immunity, etc. )
- Identify the contribution of the various arms of the immune response to protection – correlates of protection particularly in wild bird
- Knowledge on immunity levels required for re-infection of same or variants
Solution Routes
- Identification of B- and T-cell epitopes that provide best protection from inactivated and vectored vaccines
- Better understanding of response to attenuated pathogens – very limited knowledge in avian species
- Identification of conserved B- and T-cell epitopes within and between virus subtypes for targeting by vaccines
- Role of unregulated cytokine expression in production of vaccine associated enhanced respiratory disease of swine
- Immune correlates of vaccine-induced protection
- More reliable in vitro assays that can measure correlate of protection
Dependencies
- Development of rapid or reliable in vitro assays superior to HI /VN that also account for cellular and mucosal immune response and correlate with protection
Projects
What activities are planned or underway?
Protect wildlife from livestock diseases.
Planned Completion date 07/10/2022
Participating Country(s):
Netherlands
Dynamics of sustainability in integrated agriculture : aquaculture systems in the Mekong Delta
Planned Completion date 21/10/2024
Participating Country(s):
Netherlands