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Influenza roadmap:
Vaccines

Roadmap for the development of candidate vaccines for influenza

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Antibody response

Antibody response

Research Question

  • Identification of antibody that elicit protection to influenza infections – establish the contribution of the antibody response to protection

Research Gaps and Challenges

  • Identify immune correlates of protection in different breeds and ages
  • How long antibody last?
    Ability to detect antibodies, lack of sensitivity (e.g. capacity of antibodies to limit virus entry in the cell sometimes last longer than our capacity to detect it by HAI essays)

Solution Routes

  • Studies to understand why the presence of antibody titres is not a necessary prediction of protection against
    infection/mortality/shedding.
  • Passive transfer studies to establish the role of antibodies in protection
  • Identification of antibody epitopes important for antigenic drift in swine and avian species
  • Development of models to predict epitopes based on HA sequence evolution
  • Evolutionary models that can predict direction of epitope changes
  • Recommendations of when vaccines need to be updated based on antigenic drift

State Of the Art

  • Study on antigenic drift has been done in human studies but not in animal species

Projects

What activities are planned or underway?

Protect wildlife from livestock diseases.

Planned Completion date 07/10/2022

Participating Country(s):

NetherlandsIconNetherlands

Dynamics of sustainability in integrated agriculture : aquaculture systems in the Mekong Delta

Planned Completion date 21/10/2024

Participating Country(s):

NetherlandsIconNetherlands