Influenza roadmap:
Vaccines
Roadmap for the development of candidate vaccines for influenza
Download Influenza-vaccine-development-roadmapA
Antibody response
Antibody response
Research Question
- Identification of antibody that elicit protection to influenza infections – establish the contribution of the antibody response to protection
Research Gaps and Challenges
- Identify immune correlates of protection in different breeds and ages
- How long antibody last?
Ability to detect antibodies, lack of sensitivity (e.g. capacity of antibodies to limit virus entry in the cell sometimes last longer than our capacity to detect it by HAI essays)
Solution Routes
- Studies to understand why the presence of antibody titres is not a necessary prediction of protection against
infection/mortality/shedding. - Passive transfer studies to establish the role of antibodies in protection
- Identification of antibody epitopes important for antigenic drift in swine and avian species
- Development of models to predict epitopes based on HA sequence evolution
- Evolutionary models that can predict direction of epitope changes
- Recommendations of when vaccines need to be updated based on antigenic drift
State Of the Art
- Study on antigenic drift has been done in human studies but not in animal species
Projects
What activities are planned or underway?
Impact of host age on viral and bacterial communities in a waterbird population.
Planned Completion date 01/11/2022
Source Countries:
Netherlands
planning for emerging infectious disease pandemics
Planned Completion date 26/07/2021
Source Countries:
Netherlands