African Swine Fever roadmap:
Vaccines
Roadmap for the development of a candidate vaccine for ASF
Download ASF Vaccine Roadmap16
Identity of mechanisms of protection
Dependencies
Next steps
Identity of mechanisms of protection
Research Question
- Identify the mechanisms operating in immune animals, establishing the role of Abs and CMI in preventing and clearing infection
Research Gaps and Challenges
- Identify mechanisms responsible for animal survival following infection, including the mechanisms involved in the protective immune responses
- Identify viral genetic patterns that correlate with presence/absence of homologous versus heterologous protection
- Identify mechanism of homologous and heterologous resistance to develop disease upon infection among different species (also disease tolerance and susceptibility)
Solution Routes
- Identify the role of Ab and CMI in providing protection against infection – passive transfer experiments
- Establish the role of the various cell types and cytokine responses in
clearing infection - Establish the identity of the leukocytes that are effective in eliminating
infected macrophages - Determine patterns of activation of immunologically relevant host genes
Dependencies
- Improve understanding of host virus interaction at the level of the infected cells
- Genome sequence of various ASFV isolates
Projects
What activities are planned or underway?
African Swine Fever virus inactivation by feed additives in vitro
Planned Completion date 01/01/2022
Source Countries:
Netherlands
The incursion risk of African swine fever for the Netherlands by human-mediated routes
Planned Completion date 01/01/2022
Source Countries:
Netherlands