African Swine Fever roadmap:
Vaccines
Roadmap for the development of a candidate vaccine for ASF
Download ASF Vaccine RoadmapB
Cell-mediated immunity
Cell-mediated immunity
Research Question
- To establish the role of cell- mediated immune responses in protection
Research Gaps and Challenges
- Investigate the role of CTL for different genotypes
- Identify the effectors cells (cell/subtypes population)
- Investigate the role of local immunity
Solution Routes
- Monitor the cellular response to infection with different strains at different stages of infection and in recovered animals
- Passive transfer and challenge experiments
State Of the Art
- CD8 + lymphocytes also appear to have a role in the protective immune response to ASFV infection – Depletion of CD8+ T cells abrogates protection
Projects
What activities are planned or underway?
African Swine Fever virus inactivation by feed additives in vitro
Planned Completion date 01/01/2022
Source Countries:
Netherlands
The incursion risk of African swine fever for the Netherlands by human-mediated routes
Planned Completion date 01/01/2022
Source Countries:
Netherlands