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Porcine Reproductive & Respiratory Syndrome roadmap:
Vaccines

Roadmap for development of a candidate vaccine for PRRSV

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Identity of mechanisms of protection

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Dependencies

Next steps

To identify protective mechanisms in PRRSV infected animals

Research Question

  • Identify the mechanisms operating in immune animals, establishing the role of Abs and CMI in preventing and clearing infection.

Solution Routes

  • To identify the role of Ab and CMI in providing protection against infection – passive transfer experiments
  • To establish the role of the various cell types and cytokine responses in clearing infection
  • Establishing the identity of the leukocytes that are effective in eliminating infected mø

Dependencies

  • An improved understanding of host virus interaction at the level of the infected cells
  • The genome sequence of various PRRSV isolates

Projects

What activities are planned or underway?

Immune responses induced by inactivated Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) vaccine in neonate pigs using different adjuvants

Planned Completion date 01/02/2021

Source Countries:

NetherlandsIconNetherlands

Additional file 1 of Analysis of ORF5 sequences of Porcine Reproductive and Respiratory Syndrome virus (PRRSV) circulating within swine farms in Costa Rica

Planned Completion date 01/01/2021

Source Countries:

NetherlandsIconNetherlands