Porcine Reproductive & Respiratory Syndrome roadmap:
Vaccines
Roadmap for development of a candidate vaccine for PRRSV
Download PRRSV Vaccine Roadmap12
Identity of virulence factors
Dependencies
- 13 Identity of virulence factors
- 14 Identity of immunomodulators
- 15 Host responses to natural infection
- 16 Identity of mechanisms of protection
- 16A Antibody response
- 16B Cell-mediated immunity
Next steps
- 9 Adjuvant
- 10 Expression system
- 11 Vector
Identity of protective antigens
Research Question
- The identity of the virus components (epitopes) that the host needs to respond to to prevent and clear infection
Research Gaps and Challenges
- The dominant immunogens may not be protective so a range of possible antigens will need to be considered
- There is a lot of antigenic variability and genetic drift from the high mutation rate of the virus so identifying the most stable/conserved antigens is important
Solution Routes
- The identity of the antigens that the host is generating Abs to and their role in protection (preventing and clearing infection)
- To identify the antigens that are responsible for protective cellular responses
- Identifying possible protective antigens in the virus genome, their expression and trial in challenge experiments
Dependencies
- Identity of protective mechanisms operating in immune hosts – the role of neutralising Abs and CTCs
- The genome sequence of various virus isolates
Projects
What activities are planned or underway?
Immune responses induced by inactivated Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) vaccine in neonate pigs using different adjuvants
Planned Completion date 01/02/2021
Source Countries:
Netherlands
Additional file 1 of Analysis of ORF5 sequences of Porcine Reproductive and Respiratory Syndrome virus (PRRSV) circulating within swine farms in Costa Rica
Planned Completion date 01/01/2021
Source Countries:
Netherlands