Home African Swine Fever [Identity of protective antigens] Identity of protective antigens of ASF virus
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Vaccines

Roadmap for the development of a candidate vaccine for ASF

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Identity of protective antigens

Identity of protective antigens

Research Question

  • The identity of the virus components (epitopes) that the host needs to respond to prevent and/or clear infection

Research Gaps and Challenges

  • The dominant immunogens may not be the most protective, thus a range of possible antigens will need to be considered
  • Investigate gene functions
  • Investigate the need of chaperon for proper folding of proteins
  • Investigate if different antigens provoke a response in wild boars and pigs
  • Induction of a neutralising immune response

Solution Routes

  • Identify possible protective antigens in the virus genome, their expression and trial in challenge experiments
  • Identify the antigens that the host is generating Abs to and their role in protection (preventing and clearing infection)
  • Identify the antigens that are responsible for protective cellular
    responses

Dependencies

  • Identify protective mechanisms operating in immune hosts – the role of neutralising Abs and CTCs
  • The genome sequence of various virus isolates
  • Identify determinant of virulence

State Of the Art

  • Neutralising antibodies directed against virion proteins p30, p54, and p72 have been described but they are not sufficient for antibody-mediated protection
  • Partial protection was achieved using a combination of two recombinant proteins, p54 and p30, as well as with recombinant CD2-like protein but failed to give protection against highly virulent isolates

Projects

What activities are planned or underway?

African Swine Fever virus inactivation by feed additives in vitro

Planned Completion date 01/01/2022

Source Countries:

NetherlandsIconNetherlands

The incursion risk of African swine fever for the Netherlands by human-mediated routes

Planned Completion date 01/01/2022

Source Countries:

NetherlandsIconNetherlands