African Swine Fever roadmap:
Vaccines
Roadmap for the development of a candidate vaccine for ASF
Download ASF Vaccine Roadmap12
Identity of protective antigens
Identity of protective antigens
Research Question
- The identity of the virus components (epitopes) that the host needs to respond to prevent and/or clear infection
Research Gaps and Challenges
- The dominant immunogens may not be the most protective, thus a range of possible antigens will need to be considered
- Investigate gene functions
- Investigate the need of chaperon for proper folding of proteins
- Investigate if different antigens provoke a response in wild boars and pigs
- Induction of a neutralising immune response
Solution Routes
- Identify possible protective antigens in the virus genome, their expression and trial in challenge experiments
- Identify the antigens that the host is generating Abs to and their role in protection (preventing and clearing infection)
- Identify the antigens that are responsible for protective cellular
responses
Dependencies
- Identify protective mechanisms operating in immune hosts – the role of neutralising Abs and CTCs
- The genome sequence of various virus isolates
- Identify determinant of virulence
State Of the Art
- Neutralising antibodies directed against virion proteins p30, p54, and p72 have been described but they are not sufficient for antibody-mediated protection
- Partial protection was achieved using a combination of two recombinant proteins, p54 and p30, as well as with recombinant CD2-like protein but failed to give protection against highly virulent isolates
Projects
What activities are planned or underway?
Africa's Long Depression: The Growth and Debt Crises of 1975-2000
Planned Completion date 01/03/2027
Participating Country(s):
United Kingdom
Mechanistic and Pathway Analysis of Animal Influenza Virus cross-species transmission by constructing genotype and phenotype networks
Planned Completion date 01/02/2028
Participating Country(s):
United Kingdom