Roadmap for the development of candidate vaccines for liver fluke
Download Liver-Fluke-Vaccine-Roadmap-113
Identity of virulence factors
Dependencies
- 17 Host pathogen interactions
- 17A Entry
- 17B Replication
- 17C Persistence clearance
Next steps
Research Question
What are we trying to achieve and why? What is the problem we are trying to solve?
To identify the factors that aid parasite migration and feeding. If the host could be immunised against these would it result in the parasite being unable to feed.
Research Gaps and Challenges
What are the scientific and technological challenges (knowledge gaps needing to be addressed)?
Understanding how the parasite interacts with and moves across the host intestine
Solution Routes
What approaches could/should be taken to address the research question?
- Studies on the immune responses of naturally exposed animals to establish the direction of immunomodulation
- Establish which parasite genes are being expressed at different stages and their role in parasite migration/feeding
- An SFI Research Professorship to J.P. Dalton at NUIG will commence in 2019
- A number of national projects on fluke immunology and fluke vaccines are underway in Spain
Dependencies
What else needs to be done before we can solve this need?
An improved understanding of Host-parasite interaction
State Of the Art
Existing knowledge including successes and failures
Projects
What activities are planned or underway?
Single-nucleotide polymorphisms in the beta-tubulin gene and its relationship with treatment response to albendazole in human soil-transmitted helminths in Southern Mozambique
Planned Completion date 14/09/2022
Netherlands
BruchidRESIST: The Pannonian vetch (Vicia pannonica) as a model plant for the development of resistant field bean and vetch varieties against field bean weevil (Bruchus rufimanus) infestation (BruchidRESIST)
Planned Completion date 31/01/2028
Denmark