Home Influenza [Identity of virulence factors] Identity of virulence factors
Influenza roadmap:
Vaccines

Roadmap for the development of candidate vaccines for influenza

Download Influenza-vaccine-development-roadmap

13

Identity of virulence factors

Identity of virulence factors

Research Question

  • Molecular determinants of virulence and immune evasion in target
    species

Research Gaps and Challenges

  • Increase knowledge on virulence factors

Solution Routes

  • Identify determinants of virulence, particularly in waterfowl, other
    than HA cleavage site
  • Animals model to determine virulence markers
  • Test in the model system not just rodent
  • Study the role of internal genes in virulence in different species

Dependencies

  • Identify high-reassortment strains could improve pandemic
    preparedness or reveal new treatments (see disease control roadmap)
  • Viral, host and environment factors that influence the risk of acquiring an HA multibasic cleavage site
  • Virus determinants ( other than MBCS ) of local replication and
    potential systemic spread in target species

Projects

What activities are planned or underway?

Protect wildlife from livestock diseases.

Planned Completion date 07/10/2022

Participating Country(s):

NetherlandsIconNetherlands

Dynamics of sustainability in integrated agriculture : aquaculture systems in the Mekong Delta

Planned Completion date 21/10/2024

Participating Country(s):

NetherlandsIconNetherlands