Home ‹ Porcine Reproductive & Respiratory Syndrome ‹ [Identity of virulence factors] To establish the identity of the virulence factors in PRRSV that contribute to disease pathology
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Roadmap for development of a candidate vaccine for PRRSV

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13

Identity of virulence factors

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Dependencies

Next steps

To establish the identity of the virulence factors in PRRSV that contribute to disease pathology

Research Question

  • Identifying and removal of the factors contributing to pathological changes are essential for generating rationally attenuated vaccines

Solution Routes

  • Swapping of suspected virulence genes between virulent and attenuated viruses using infectious cDNA clones
  • Generation of a range of knock-out viruses and their use in experimental infections to establish the impact of the changes on virulence

Dependencies

  • Improved understanding of virus macrophage interaction – viral and macrophage gene expression in different in vivo environments (macrophages from naïve and immune hosts)

Projects

What activities are planned or underway?

Immune responses induced by inactivated Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) vaccine in neonate pigs using different adjuvants

Planned Completion date 01/02/2021

Source Countries:

NetherlandsIconNetherlands

Additional file 1 of Analysis of ORF5 sequences of Porcine Reproductive and Respiratory Syndrome virus (PRRSV) circulating within swine farms in Costa Rica

Planned Completion date 01/01/2021

Source Countries:

NetherlandsIconNetherlands