African Swine Fever roadmap:
Diagnostic Tests
Roadmap for the development of diagnostic tests for ASF
Download ASF Diagnostic Roadmap6
Immune response
Dependencies
- 7 Host-pathogen interactions
- 7A Entry
- 7B Replication
- 7C Persistence/ clearance
- 8 Antigen detection
Next steps
- 5 Stage-specific antigens
Detection of immune response in ASFV infected animals
Research Question
- The clarification of the immune response mechanisms in infected animals, as to improve detection of infected animals
Research Gaps and Challenges
- Understanding the actual role of virus driven host immunomodulation in the process of virus infection in swine
- Find specific host reactivity pattern
Solution Routes
- Determine patterns of activation of immunologically relevant host genes. Use of transcriptomics technology to identify specific host reactivity pattern
Dependencies
- Improve understanding of host virus interaction at the level of the infected cells
- Infection studies under BSL3AG
State Of the Art
- Advances have been achieved in identifying and understanding the function of virus genes modulating the host response and its direct effect during the process of infection in the natural host
Projects
What activities are planned or underway?
Africa's Long Depression: The Growth and Debt Crises of 1975-2000
Planned Completion date 01/03/2027
Participating Country(s):
United Kingdom
Mechanistic and Pathway Analysis of Animal Influenza Virus cross-species transmission by constructing genotype and phenotype networks
Planned Completion date 01/02/2028
Participating Country(s):
United Kingdom