Brucellosis roadmap:
Vaccines
Roadmap for development of a candidate vaccine for Brucella
Download Roadmap-for-a-brucella-vaccine-v14
Development of a killed/inactivated Brucella vaccine
Dependencies
Next steps
Inactivated Vaccines
Research Question
- The development of an effective killed vaccine that can be used in pregnant animals.
Research Gaps and Challenges
- Having the protective response involving both Abs and CTC
Solution Routes
- Generation of a range of recombinant organisms expressing protective Antigens from a range of Brucella species.
- Monitoring the immune response following immunisation with the various candidates.
- Challenge experiments with the various vaccine candidates.
Dependencies
- Identifying a combination of antigens for expression by a GM strain of Brucella
- The availability of suitable adjuvants to stimulate strong CTC and Ab responses.
Projects
What activities are planned or underway?
Estimates of disease burden caused by foodborne pathogens in contaminated dairy products in Rwanda.
Planned Completion date 06/04/2023
Source Countries:
Netherlands
An overview of current approaches and challenges to the control of endemic infectious cattle diseases in Albania
Planned Completion date 14/07/2021
Source Countries:
Netherlands