African Swine Fever roadmap:
Vaccines
Roadmap for the development of a candidate vaccine for ASF
Download ASF Vaccine Roadmap4
Inactivated vaccines
Inactivated vaccines
Research Question
- The development of an effective killed virus vaccine that provide protection and is safe
Research Gaps and Challenges
- Having it efficacious
- Cross protection
- Stimulating protective response involving both VN Abs and CTC
Solution Routes
- Selection of inactivated whole virus preparations
- Monitoring the immune response following immunisation with the various candidates.
- Challenge experiments with the various vaccine candidates
Dependencies
- Selection of the right strain, titre and preparation/inactivation to induce a protective immunity
- The availability of suitable adjuvants to stimulate strong CTC and VN-Ab responses
State Of the Art
- Attempts to vaccinate animals using infected cell extracts, supernatants of infected pig peripheral blood leukocytes, purified and inactivated virions, infected glutaraldehyde-fixed macrophages, or detergent-treated infected alveolar macrophages failed to induce protective immunity
Projects
What activities are planned or underway?
Africa's Long Depression: The Growth and Debt Crises of 1975-2000
Planned Completion date 01/03/2027
Participating Country(s):
United Kingdom
Unlocking potential: developing innovative adolescent screening visits for health promotion, prevention and treatment in low-resource settings
Planned Completion date 01/01/2028
Participating Country(s):
United Kingdom