Roadmap for Immunomodulators

What are we trying to achieve and why? What is the problem we are trying to solve?

Investigating impact of live vaccines.

What are the scientific and technological challenges (knowledge gaps needing to be addressed)?

Live vaccines delivered to the gut can induce an immune response in addition to generating an exclusion effect.
Live vaccines delivered parenterally can also induce innate immunity which can be cross protective against unrelated bacterial pathogens.
Adjuvant as innate modulator for training or tolerance.
Integrated immunology needed rather than separation of innate and adaptive
understanding of ecology and evolution and pathogens.

What approaches could/should be taken to address the research question?

Further experimental in vivo studies.

What else needs to be done before we can solve this need?

Safety – vaccine might be damaging in the long term and should not select for escape variants- understanding of ecology and evolution and pathogens in a vaccinated and unvaccinated or partially vaccinated world.

Existing knowledge including successes and failures