Roadmap for the development of candidate vaccines for FMD

What are we trying to achieve and why? What is the problem we are trying to solve?

Establish and define the importance of cell-mediated immune response to FMDV

What are the scientific and technological challenges (knowledge gaps needing to be addressed)?

• Define immunological parameters involved in protection against homologous and heterologous infection, besides antibody titres
• Investigate the importance of T-cell responses to optimise vaccine-induced immunity
• Explore potential of CD8 T-cell stimulation, especially in ruminants
• Investigate the role of mucosal immunity

What approaches could/should be taken to address the research question?

Transfer experiments

What else needs to be done before we can solve this need?

Details of host-pathogen interactions

Existing knowledge including successes and failures