Helminths (including anthelmintic resistance) roadmap:
Therapeutics
Roadmap for development of therapeutics for helminths
Download Helminths-Therapeutic-Tests-Roadmap9
Mode of action/Resistance
Dependencies
- 11 Target Identification
- 11A Phenotypic
- 11B Mechanism-based
Next steps
- 5 Pharmacology
- 5A Drug design
- 5B PK/PD integration
- 5C Combination of drugs/API
- 5D Formulation delivery routes
- 11 Target Identification
- 11A Phenotypic
- 11B Mechanism-based
- 10 Test for drug resistance
- 10A Clinical
- 10B Genetic
Mode of action/Resistance
Research Question
See text in Lead Summaries 1, 5 and 14.
Research Gaps and Challenges
What are the scientific and technological challenges (knowledge gaps needing to be addressed)?
Solution Routes
What approaches could/should be taken to address the research question?
Dependencies
What else needs to be done before we can solve this need?
State Of the Art
Existing knowledge including successes and failures
Projects
What activities are planned or underway?
Single-nucleotide polymorphisms in the beta-tubulin gene and its relationship with treatment response to albendazole in human soil-transmitted helminths in Southern Mozambique
Planned Completion date 14/09/2022
Source Countries:
Netherlands
BruchidRESIST: The Pannonian vetch (Vicia pannonica) as a model plant for the development of resistant field bean and vetch varieties against field bean weevil (Bruchus rufimanus) infestation (BruchidRESIST)
Planned Completion date 31/01/2028
Source Countries:
Denmark