African Swine Fever roadmap:
Vaccines
Roadmap for the development of a candidate vaccine for ASF
Download ASF Vaccine Roadmap2
Naturally attenuated candidates
Naturally attenuated candidates
Research Question
- The development of a cross protective ASF vaccine by passage in tissue culture or a mutant low pathogenic wild type strain
Research Gaps and Challenges
- Lack of cross protection among different isolates
- Risk of reversion to virulence
Solution Routes
- Perform passage in tissue culture to reduce virulence
- Identify mutant low pathogenic wild strains
Dependencies
- Identify strains that give greatest cross protection
- Develop suitable cell lines for high titre propagation and licensing
State Of the Art
- Experimentally, some level of homologous protection can be achieved by inoculation of pigs with low-virulence isolates obtained by passage in tissue culture or by deletion of genes involved in virulence, as well as low virulence isolates from the field
- Challenge models have been evaluated and are available
Projects
What activities are planned or underway?
Africa's Long Depression: The Growth and Debt Crises of 1975-2000
Planned Completion date 01/03/2027
Participating Country(s):
United Kingdom
Mechanistic and Pathway Analysis of Animal Influenza Virus cross-species transmission by constructing genotype and phenotype networks
Planned Completion date 01/02/2028
Participating Country(s):
United Kingdom