Coronaviruses roadmap:
Diagnostic Tests
Roadmap for the development of diagnostic tests for coronaviruses
Download 202410 Draft Coronavirus Diagnostic Development_Final9
Organism detection
Organism detection
Research Question
- Coronavirus detection in different species and matrix
Research Gaps and Challenges
- Cost-effectiveness of sampling strategy
- Interpretation of detection or assay results in different species/matrices, i.e., setting the specificity and sensitivity in different species context
- Field tests associated with early reporting systems
- Sampling from wildlife (e.g. bats)
- Organism detection requires active infection or presence of virus nucleic acid, not indicative of exposure
Solution Routes
- Protocols to work through co-infections in order to capture all pathogens (virome/metagenomics)
- NGS for in-field application and affordable
- Rapid sensitive and specific methods for field detection (pen-side or LFT)
Dependencies
- Prediction models
- Defining diagnostics needs according to region, species etc
- Understanding specific CoV ecology in order to implement surveillance
State Of the Art
- Organism detection is particularly important in herd diagnostics when antibody response might be unclear, e.g. other infections and/or young age for maternal immunity
Projects
What activities are planned or underway?
Differential susceptibility of SARS-CoV-2 in animals : Evidence of ACE2 host receptor distribution in companion animals, livestock and wildlife by immunohistochemical characterisation
Planned Completion date 26/07/2021
Participating Country(s):
Netherlands
Veterinary Biocontained facility Network for excellence in animal infectiology research and experimentation
Planned Completion date 28/02/2023
Participating Country(s):
Europe