Influenza roadmap:
Control Strategies
Roadmap for the development of disease control strategies for influenza
Download Influenza-control-development-roadmap14
Pathogen genome
Pathogen genome
Research Question
- Understand the influenza genome (pathogenicity, immune suppression, adaptation to new species, ecology, impact of interventions such as vaccination on evolution, etc.)
- What allows LPAIV to switch to HPAIV in H5 and H7 and not in other subtypes
- What makes the AI to change into a strain dangerous for humans
Research Gaps and Challenges
- Reassortment and continuing spread of H5N8 (goose Guandong lineage H5 viruses)
- Rate of genetic change and factors affecting
- Mechanisms of gene reassortment between virus subtypes
Solution Routes
- Continuing development of NGS-based whole genome sequencing
- Effective deployment of 3rd -gen sequencing technologies for both wet- and dry-lab protocols, allowing point-of-incidence analysis
- Maps of virulence signatures for artificial intelligence / machine learning algorithms that can better link genotype to phenotype
- Molecular signatures in viruses associated with improved environmental stability (effect of ammonia , temperature ) and vaccination
- Sequences and metadata from viruses in a broad variety of hosts and under varied conditions
- Sequences from IAV events in which various viral phenotypes are suspected (aerosol transmission, survival in the environment,
multi-species infection, etc.)
Dependencies
- Improved data sharing of sequences – especially in real time
- Mechanisms of intra-host virus evolution
Projects
What activities are planned or underway?
Development of Vaccines for HPAI in Cattle, Turkey, Pigs, and Small Ruminants and Food Safety Studies Related to HPAI Virus in Food Products
Planned Completion date 25/08/2029
Source Countries:
United States
Automated non-invasive Detection of Surface Contamination and Optimizing Surface Biofilm Removal Conditions in Large-Scale Food Processing Equipment
Planned Completion date 31/08/2028
Source Countries:
United States