African Swine Fever roadmap:
Vaccines
Roadmap for the development of a candidate vaccine for ASF
Download ASF Vaccine Roadmap3
Rationally attenuated candidates
Rationally attenuated candidates
Research Question
- Replicating ASFV are likely to give the most appropriate immune response but wild-type virus manipulates the host response. The aim is to reduce the virulence so that the vaccinated animal can mount a protective immune response. (The vaccine should allow the differentiation between infected and vaccinated animals)
Research Gaps and Challenges
- Lack of heterologous protection
- Possible link between immunogenicity and pathogenicity of the virus
- Ensure that vaccination prevents excretion of the organism – both the vaccine strain and wild type virus or any combination of the two that may have been generated
- Achieve long duration and fast onset of immunity
- Determine safety characteristics associated with experimental live attenuated
vaccines - Development of recombinant ASFV is still laborious
Solution Routes
- Identify suitable strains
- Create GM organisms lacking virulence and immunomodulatory factors
- Monitor the immune response following immunisation with the various candidates
- Develop improved systems to manipulate ASFV
- Perform challenge experiments with the various vaccine candidates, including challenge with other strains
- Identify more suitable cell lines for ASFV production
Dependencies
- Generate stable genetically modified attenuated organisms
- Identify virulence factors in ASFV
- Identify immunomodulators in ASFV
- Identify gene function ASFV
- Identify correlates of protection
- (Identify DIVA targets)
- Immune response: identify mechanism of immune evasion, and mechanism of protective immunity
- Better understand virus replication
- Develop suitable cell lines for production
State Of the Art
- Pigs immunised with live attenuated ASF viruses containing engineered deletions of specific ASFV virulence/host range genes could be protected to different levels when challenged with homologous parental virus
Projects
What activities are planned or underway?
Africa's Long Depression: The Growth and Debt Crises of 1975-2000
Planned Completion date 01/03/2027
Participating Country(s):
United Kingdom
Unlocking potential: developing innovative adolescent screening visits for health promotion, prevention and treatment in low-resource settings
Planned Completion date 01/01/2028
Participating Country(s):
United Kingdom