Porcine Reproductive & Respiratory Syndrome roadmap:
Vaccines
Roadmap for development of a candidate vaccine for PRRSV
Download PRRSV Vaccine Roadmap6
Subunit vaccines
Development of a cross protective/multivalent subunit vaccine
Research Question
- The development of an effective subunit vaccine that gives broad cross-protective sterile immunity but doesn’t contribute to virus evolution
Research Gaps and Challenges
- Having it multivalent
- Having the protective response involving both VN-Abs and CTC
Solution Routes
- Establishing that there isn’t interference between the various antigens
- Monitoring the immune response following immunisation with the various combinations of candidate immunogens
- Challenge experiments with the various vaccine candidates
- If a multivalent vaccine isn’t possible then strain specific autologous vaccines based on recognised antigen combinations will be needed
- Production of virus-like particles containing all the desired surface proteins of PRRSV
Dependencies
- Identifying a combination of antigens for expression by a suitable expression vector or a common single Ag to which immune responses are normally suppressed
- The availability of suitable adjuvants to stimulate strong CTC and VNAb responses
- Identifying expression systems that give correct antigen conformation
Projects
What activities are planned or underway?
Immune responses induced by inactivated Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) vaccine in neonate pigs using different adjuvants
Planned Completion date 01/02/2021
Source Countries:
Netherlands
Additional file 1 of Analysis of ORF5 sequences of Porcine Reproductive and Respiratory Syndrome virus (PRRSV) circulating within swine farms in Costa Rica
Planned Completion date 01/01/2021
Source Countries:
Netherlands