Home Influenza [Validation/ proficiency] Validation
Influenza roadmap:
Diagnostic Tests

Roadmap for the development of diagnostic test for influenza

Download Influenza-diagnostic-development-roadmap

2

Validation/ proficiency

Validation

Research Question

  • Validation of diagnostics tools

Research Gaps and Challenges

  • Validation of existing diagnostics against novel isolates
  • Lack of harmonized validation protocols
  • Development of internal controls that are standardized and readily shared
  • Validation of portable PCR
  • Validation of serologic DIVA tests to understand levels of sampling to achieve goal to show freedom from disease
  • Understand how NGS can be used to supplement/augment PCR testing
  • Validation of use for minor species (9000 avian species!!) and age of animal (e.g. piglets and sows)
  • The chances of independent and external validation are rare and its cost may be expensive
  • Lack of reference material

Solution Routes

  • Standardization of methods across labs – ring trials
  • Co-ordinated lines of reference material production
  • Orchestrated collections of field material
  • Improve broad detection, sensitivity and specificity of diagnostic tests
  • Validation of portable PCR
  • Validation of serologic DIVA tests to understand levels of sampling to achieve goal to show freedom from disease
  • Understand how NGS can be used to supplement/augment PCR testing
  • Public/private partnerships – letting private companies have access to samples and share technologies with companies despite restrictions in sampling handling of material from HPAI/regulated diseases

Dependencies

  • Reference materials
  • Organizational structures of concerted validation lines.
  • Availability of economic resources

Projects

What activities are planned or underway?

Protect wildlife from livestock diseases.

Planned Completion date 07/10/2022

Participating Country(s):

NetherlandsIconNetherlands

Impact of host age on viral and bacterial communities in a waterbird population.

Planned Completion date 01/11/2022

Participating Country(s):

NetherlandsIconNetherlands