African Swine Fever roadmap:
Vaccines
Roadmap for the development of a candidate vaccine for ASF
Download ASF Vaccine Roadmap11
Vector
Dependencies
Next steps
- 7 Vectored vaccines
- 7A Safety
- 7B Delivery route
- 7C Delivery platform
- 7D Efficacy in challenge model
Vector
Research Question
- The identification of a suitable vector for the expression/delivery of protective ASFV antigens
Research Gaps and Challenges
- Ensure the expression of the antigens to induce a protective immune response.
- Identify the best vector among those that already went through the regulatory process.
- Create stable genetically modified organisms expressing the desired ASFV antigens
Solution Routes
- Generate genetically modified organisms (viruses or bacteria) expressing the protective antigens of different ASFV strains
- Use recombinant vaccine strains containing individual ASFV gene/s as vectors
- Use recombinant ASFV subunit vaccines using swinepox virus as vector
- Incorporate molecular adjuvants (expressing CD40 ligand)
Dependencies
- Identify the most appropriate antigens
- Ensure sufficient expression level
- Develop capacity to test the expression
- Identify the most suitable delivery systems (e.g. oral for wild suids in Europe)
- Identify vectors being suitable for one dose administration
Projects
What activities are planned or underway?
Africa's Long Depression: The Growth and Debt Crises of 1975-2000
Planned Completion date 01/03/2027
Participating Country(s):
United Kingdom
Mechanistic and Pathway Analysis of Animal Influenza Virus cross-species transmission by constructing genotype and phenotype networks
Planned Completion date 01/02/2028
Participating Country(s):
United Kingdom