Home ‹ Porcine Reproductive & Respiratory Syndrome ‹ [Vector] Identifying suitable vector for the expression/delivery of protective PRRSV Antigens
Porcine Reproductive & Respiratory Syndrome roadmap:
Vaccines

Roadmap for development of a candidate vaccine for PRRSV

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11

Vector

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Dependencies

Next steps

  • 7 Vectored vaccines
  • 7A Safety
  • 7B Delivery route
  • 7C Delivery platform
  • 7D Efficacy in challenge model
Identifying suitable vector for the expression/delivery of protective PRRSV Antigens

Research Question

  • The generation of protective responses without the risk of the recombination between an attenuated strain and wild strains

Research Gaps and Challenges

  • The expression of the protective antigens by a replicating organism with the development of VN-Abs and CTC responses
  • Creating stable genetically modified organisms expressing the desired PRRSV antigens
  • Identifying the Ag combination to give widest protection against the various field isolates

Solution Routes

  • Generation of genetically modifies organisms (viruses or bacteria) expressing the protective antigens of different PRRSV strains
  • Incorporation of molecular adjuvants (expressing CD40 ligand)

Dependencies

  • Identity of the most appropriate antigens

Projects

What activities are planned or underway?

Immune responses induced by inactivated Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) vaccine in neonate pigs using different adjuvants

Planned Completion date 01/02/2021

Source Countries:

NetherlandsIconNetherlands

Additional file 1 of Analysis of ORF5 sequences of Porcine Reproductive and Respiratory Syndrome virus (PRRSV) circulating within swine farms in Costa Rica

Planned Completion date 01/01/2021

Source Countries:

NetherlandsIconNetherlands