Roadmap for the development of candidate vaccines for liver fluke
Download Liver-Fluke-Vaccine-Roadmap-111
Vector
Dependencies
Next steps
- 7 Vectored vaccines
- 7A Safety
- 7B Delivery route
- 7C Delivery platform
- 7D Efficacy in challenge model
Research Question
What are we trying to achieve and why? What is the problem we are trying to solve?
Using a replicating organism to express the protective antigens generating a stronger longer-lasting immune response
Research Gaps and Challenges
What are the scientific and technological challenges (knowledge gaps needing to be addressed)?
Immune response against the vector
Solution Routes
What approaches could/should be taken to address the research question?
Explore a range of possible vectors – large viruses (Herpes viruses, endogenous retroviruses), protozoa (Trypanosoma theileri, Eimeria), bacteria (replication deficient such as aroA mutants)
Dependencies
What else needs to be done before we can solve this need?
- Identity of the protective antigens
- Successful antigen expression
State Of the Art
Existing knowledge including successes and failures
No specific trials with Fasciola antigens as yet.
Projects
What activities are planned or underway?
Single-nucleotide polymorphisms in the beta-tubulin gene and its relationship with treatment response to albendazole in human soil-transmitted helminths in Southern Mozambique
Planned Completion date 14/09/2022
Netherlands
BruchidRESIST: The Pannonian vetch (Vicia pannonica) as a model plant for the development of resistant field bean and vetch varieties against field bean weevil (Bruchus rufimanus) infestation (BruchidRESIST)
Planned Completion date 31/01/2028
Denmark