Home Helminths (including anthelmintic resistance) [Vector] – Vector identification for Vectored vaccine – Liver Fluke
Helminths (including anthelmintic resistance) roadmap:
Vaccines

Roadmap for the development of candidate vaccines for liver fluke

Download Liver-Fluke-Vaccine-Roadmap-1

11

Vector

Dependencies

Next steps

  • 7 Vectored vaccines
  • 7A Safety
  • 7B Delivery route
  • 7C Delivery platform
  • 7D Efficacy in challenge model
Vector identification for Vectored vaccine

Research Question

What are we trying to achieve and why? What is the problem we are trying to solve?

Using a replicating organism to express the protective antigens generating a stronger longer-lasting immune response

Research Gaps and Challenges

What are the scientific and technological challenges (knowledge gaps needing to be addressed)?

Immune response against the vector

Solution Routes

What approaches could/should be taken to address the research question?

Explore a range of possible vectors – large viruses (Herpes viruses, endogenous retroviruses), protozoa (Trypanosoma theileri, Eimeria), bacteria (replication deficient such as aroA mutants)

Dependencies

What else needs to be done before we can solve this need?

  • Identity of the protective antigens
  • Successful antigen expression

State Of the Art

Existing knowledge including successes and failures

No specific trials with Fasciola antigens as yet.