Porcine Reproductive & Respiratory Syndrome roadmap:
Vaccines
Roadmap for development of a candidate vaccine for PRRSV
Download PRRSV Vaccine Roadmap7
Vectored vaccines
Development of a cross protective/multivalent vectored PRRSV vaccine
Research Question
- The development of an effective vaccine that gives broad cross-protection but doesn’t contribute to virus evolution
Research Gaps and Challenges
- Generating a strong protective immune response with CTCs and VN Abs
- Preventing the development of immune responses to the vector
Solution Routes
- Monitoring the immune response following immunisation with the various candidates involving single/combination of antigens
- Challenge experiments with the various vaccine candidates
- Development of vaccine platforms Identify most appropriate route of administration (parenteral/oral/nasal)
Dependencies
- Identifying a combination of antigens for expression by a vector or a common single Ag to which immune responses are normally suppressed
- Identifying suitable vector
Projects
What activities are planned or underway?
Immune responses induced by inactivated Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) vaccine in neonate pigs using different adjuvants
Planned Completion date 01/02/2021
Source Countries:
Netherlands
Modified live vaccine strains of porcine reproductive and respiratory syndrome virus cause immune system dysregulation similar to wild strains.
Planned Completion date 12/01/2024
Source Countries:
Netherlands