Roadmap for the development of candidate vaccines for liver fluke
Download Liver-Fluke-Vaccine-Roadmap-17
Vectored vaccines
Research Question
What are we trying to achieve and why? What is the problem we are trying to solve?
Using a replicating organism to give enhanced exposure to protective antigens
Research Gaps and Challenges
What are the scientific and technological challenges (knowledge gaps needing to be addressed)?
- If several antigens are needed to give optimal protection the vector may need to have a relatively large genome.
- That the expressed antigen has the correct conformation
- That revaccination doesn’t result in rapid elimination of the vector
Solution Routes
What approaches could/should be taken to address the research question?
Development of a range of genetically modified organisms expressing protective antigens of one or more parasite species either as a secreted entity or as a surface molecule
Dependencies
What else needs to be done before we can solve this need?
Identification of an effective and acceptable vector system
Interdisciplinary collaboration to achieve this
State Of the Art
Existing knowledge including successes and failures
There have been no studies to date on vector-expressed vaccines for Fasciola
Projects
What activities are planned or underway?
Single-nucleotide polymorphisms in the beta-tubulin gene and its relationship with treatment response to albendazole in human soil-transmitted helminths in Southern Mozambique
Planned Completion date 14/09/2022
Netherlands
BruchidRESIST: The Pannonian vetch (Vicia pannonica) as a model plant for the development of resistant field bean and vetch varieties against field bean weevil (Bruchus rufimanus) infestation (BruchidRESIST)
Planned Completion date 31/01/2028
Denmark