African Swine Fever roadmap:
Vaccines
Roadmap for the development of a candidate vaccine for ASF
Download ASF Vaccine Roadmap7
Vectored vaccines
Vectored vaccines
Research Question
- The development of a subunit vaccine where ASFV gene/s is cloned into DNA constructs that are used as immunogens, providing broad cross-protective immunity and is safe
Research Gaps and Challenges
- Identify ASFV gene products that can induce a protective immune response to engineer subunit vaccines
- Have it multivalent
- Stimulate protective response involving both VN Abs and CTC
Solution Routes
- Multimeric scaffold could be an important research target of priority
Dependencies
- Identify protective antigens and the antigen combination to give widest protection against the various field isolates
- Select the best adjuvants
- Select the best production system
- Select the best antigen presentation system, e.g. multimeric scaffold, VLPs etc
- Identify a combination of antigens that would generate protective responses or a common single antigen to which immune responses are normally suppressed
State Of the Art
- Up to now, all subunit candidates failed
Projects
What activities are planned or underway?
African Swine Fever virus inactivation by feed additives in vitro
Planned Completion date 01/01/2022
Source Countries:
Netherlands
The incursion risk of African swine fever for the Netherlands by human-mediated routes
Planned Completion date 01/01/2022
Source Countries:
Netherlands