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Foot and Mouth Disease roadmap:
Diagnostic Tests

Roadmap for the development of diagnostic tests for FMD

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                                Fit-for-purpose diagnostic tool
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                                  Lead Summary Challenges and gap analysis
                                  10 Sample type/ transportation/ preparation Sample type/transportation/preparation
                                  9B Genetic Sequencing of FMD strains
                                  9A Direct detection Direct detection and identification of FMDV
                                  9 Organism detection Identification of new sensitive media or cell line allowing easy and low-cost viral isolation
                                  8 Characterization Characterization of FMD strains
                                  7D Immune Reliable and rapid immunological tests
                                  7C Infectious Establishing the mechanisms of virus persistence/clearance from infected cells
                                  7B Exposed Development of reliable and rapid immunological tests allowing to identify exposed animals, including peri-clinical, subclinically infected and recovered animals
                                  7A Susceptible
                                  7 Host-pathogen interactions Characterising Host Pathogen interaction in FMD infection
                                  6 Biomarkers
                                  5B Cell mediated immunity Identify cell mediated immunity in response to FMDV infection
                                  5A AB Response Identify antibodies in response to FMDV infection
                                  5 Host response Investigate animal response to FMDV infection to identify diagnostic targets
                                  4 Stage Specific Response
                                  3 Tools Development of expression systems for FMD diagnostic reagents
                                  2 Validation/proficiency Diagnostic test validation for different serotypes and in field conditions
                                  1 Fit-for-purpose diagnostic tool Diagnostic tools development