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Coronaviruses roadmap:
Vaccines

Research roadmap for coronavirus vaccine development

Download 202402 Draft Coronavirus Vaccine research roadmap Final
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2

Naturally attenuated candidates
  • ASafety
  • BDelivery route
  • CDelivery platform
  • DEfficacy in challenge model
"] --> 33144["

1

Vaccine
    "] 33151["

    3

    Rationally attenuated candidates
    • ASafety
    • BDelivery route
    • CDelivery platform
    • DEfficacy in challenge model
    "] --> 33144["

    1

    Vaccine
      "] 33152["

      4

      Inactivated vaccines
      • ASafety
      • BDelivery route
      • CDelivery platform
      • DEfficacy in challenge model
      "] --> 33144["

      1

      Vaccine
        "] 33163["

        5

        DNA/RNA vaccines
        • ASafety
        • BDelivery route
        • CDelivery platform
        • DEfficacy in challenge model
        "] --> 33144["

        1

        Vaccine
          "] 33169["

          6

          Subunit vaccines
          • ASafety
          • BDelivery route
          • CDelivery platform
          • DEfficacy in challenge model
          "] --> 33144["

          1

          Vaccine
            "] 33178["

            7

            Vectored vaccines
            • ASafety
            • BPlatform route
            • CPlatform delivery
            • DEfficacy in challenge model
            "] --> 33144["

            1

            Vaccine
              "] 33187["

              9

              Adjuvant
                "] --> 33152["

                4

                Inactivated vaccines
                • ASafety
                • BDelivery route
                • CDelivery platform
                • DEfficacy in challenge model
                "] 33187["

                9

                Adjuvant
                  "] --> 33163["

                  5

                  DNA/RNA vaccines
                  • ASafety
                  • BDelivery route
                  • CDelivery platform
                  • DEfficacy in challenge model
                  "] 33187["

                  9

                  Adjuvant
                    "] --> 33151["

                    3

                    Rationally attenuated candidates
                    • ASafety
                    • BDelivery route
                    • CDelivery platform
                    • DEfficacy in challenge model
                    "] 33185["

                    8

                    Attenuated organisms
                      "] --> 33151["

                      3

                      Rationally attenuated candidates
                      • ASafety
                      • BDelivery route
                      • CDelivery platform
                      • DEfficacy in challenge model
                      "] 33185["

                      8

                      Attenuated organisms
                        "] --> 33187["

                        9

                        Adjuvant
                          "] 33188["

                          10

                          Expression system
                            "] --> 33187["

                            9

                            Adjuvant
                              "] 33189["

                              11

                              Vector
                                "] --> 33178["

                                7

                                Vectored vaccines
                                • ASafety
                                • BPlatform route
                                • CPlatform delivery
                                • DEfficacy in challenge model
                                "] 33190["

                                12

                                Identity of protective antigens
                                  "] --> 33187["

                                  9

                                  Adjuvant
                                    "] 33190["

                                    12

                                    Identity of protective antigens
                                      "] --> 33188["

                                      10

                                      Expression system
                                        "] 33190["

                                        12

                                        Identity of protective antigens
                                          "] --> 33189["

                                          11

                                          Vector
                                            "] 33192["

                                            13

                                            Identity of virulence factors
                                              "] --> 33185["

                                              8

                                              Attenuated organisms
                                                "] 33192["

                                                13

                                                Identity of virulence factors
                                                  "] --> 33190["

                                                  12

                                                  Identity of protective antigens
                                                    "] 33195["

                                                    14

                                                    Identity of immunomodulators
                                                      "] --> 33185["

                                                      8

                                                      Attenuated organisms
                                                        "] 33195["

                                                        14

                                                        Identity of immunomodulators
                                                          "] --> 33190["

                                                          12

                                                          Identity of protective antigens
                                                            "] 33197["

                                                            15

                                                            Host responses to natural infection
                                                              "] --> 33185["

                                                              8

                                                              Attenuated organisms
                                                                "] 33197["

                                                                15

                                                                Host responses to natural infection
                                                                  "] --> 33190["

                                                                  12

                                                                  Identity of protective antigens
                                                                    "] 33200["

                                                                    16

                                                                    Identity of mechanisms of protection"] --> 33190["

                                                                    12

                                                                    Identity of protective antigens
                                                                      "] 33203["

                                                                      17

                                                                      Host-pathogen interactions
                                                                      • AEntry
                                                                      • BReplication
                                                                      • CPersistence/ clearance
                                                                      "] --> 33197["

                                                                      15

                                                                      Host responses to natural infection
                                                                        "] 33203["

                                                                        17

                                                                        Host-pathogen interactions
                                                                        • AEntry
                                                                        • BReplication
                                                                        • CPersistence/ clearance
                                                                        "] --> 33195["

                                                                        14

                                                                        Identity of immunomodulators
                                                                          "] 33203["

                                                                          17

                                                                          Host-pathogen interactions
                                                                          • AEntry
                                                                          • BReplication
                                                                          • CPersistence/ clearance
                                                                          "] --> 33200["

                                                                          16

                                                                          Identity of mechanisms of protection"] 33203["

                                                                          17

                                                                          Host-pathogen interactions
                                                                          • AEntry
                                                                          • BReplication
                                                                          • CPersistence/ clearance
                                                                          "] --> 33192["

                                                                          13

                                                                          Identity of virulence factors
                                                                            "] 33207["

                                                                            18

                                                                            Challenge models
                                                                              "] --> 33203["

                                                                              17

                                                                              Host-pathogen interactions
                                                                              • AEntry
                                                                              • BReplication
                                                                              • CPersistence/ clearance
                                                                              "] 33207["

                                                                              18

                                                                              Challenge models
                                                                                "] --> 33200["

                                                                                16

                                                                                Identity of mechanisms of protection"] linkStyle default stroke-width:1px,stroke:#3bcaf2
                                                                                Lead Summary Challenges and gap analysis
                                                                                1 Vaccine Vaccine
                                                                                2D Efficacy in challenge model
                                                                                2C Delivery platform
                                                                                2B Delivery route
                                                                                2A Safety
                                                                                2 Naturally attenuated candidates Naturally attenuated candidates
                                                                                3D Efficacy in challenge model
                                                                                3C Delivery platform
                                                                                3B Delivery route
                                                                                3A Safety
                                                                                3 Rationally attenuated candidates Rationally attenuated candidates
                                                                                4D Efficacy in challenge model
                                                                                4C Delivery platform
                                                                                4B Delivery route
                                                                                4A Safety
                                                                                4 Inactivated vaccines Inactivated vaccines
                                                                                5D Efficacy in challenge model
                                                                                5C Delivery platform
                                                                                5B Delivery route
                                                                                5A Safety
                                                                                5 DNA/RNA vaccines DNA/RNA vaccines
                                                                                6D Efficacy in challenge model
                                                                                6C Delivery platform
                                                                                6B Delivery route
                                                                                6A Safety
                                                                                6 Subunit vaccines Subunit vaccines
                                                                                7D Efficacy in challenge model
                                                                                7C Platform delivery
                                                                                7B Platform route
                                                                                7A Safety
                                                                                7 Vectored vaccines Vectored vaccines
                                                                                9 Adjuvant Adjuvant
                                                                                8 Attenuated organisms Attenuated organisms
                                                                                10 Expression system Expression system
                                                                                11 Vector Vector
                                                                                12 Identity of protective antigens Identity of protective antigens
                                                                                13 Identity of virulence factors Identity of virulence factors
                                                                                14 Identity of immunomodulators Identity of immunomodulators
                                                                                15 Host responses to natural infection Host responses to natural infection
                                                                                16B Cell-mediated immunity Cell-mediated immunity
                                                                                16A Antibody response Antibody response
                                                                                16 Identity of mechanisms of protection Identity of mechanisms of protection
                                                                                17C Persistence/ clearance
                                                                                17B Replication
                                                                                17A Entry
                                                                                17 Host-pathogen interactions Host-pathogen interactions
                                                                                18 Challenge models Challenge models