Roadmap for development of a candidate vaccine for Brucella

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9

Identifying suitable delivery systems for subunit vaccine candidates, killed bacteria and DNA vaccine candidates

"] --> 32987["

4

Development of a killed/inactivated Brucella vaccine

• ASafety
• BDelivery Route
• CDelivery Platform
• DEfficacy in Challenge Model

"] 33050["

9

Identifying suitable delivery systems for subunit vaccine candidates, killed bacteria and DNA vaccine candidates

"] --> 32993["

5

Development of a DNA vaccine for Brucellosis

• ASafety
• BDelivery Route
• CDelivery Platform
• DEfficacy in Challenge Model

"] 33050["

9

Identifying suitable delivery systems for subunit vaccine candidates, killed bacteria and DNA vaccine candidates

"] --> 33032["

6

Development of a Brucella subunit vaccine

• ASafety
• BDelivery Route
• CDelivery Route
• DEfficacy in Challenge Model

"] 33048["

8

Rationally attenuated genetically modified Brucella organisms

"] --> 32982["

3

Development of a novel Brucellosis attenuated vaccine allowing DIVA

• ASafety
• BDelivery Route
• CDelivery Platform
• DEfficacy in Challenge Model

"] 33048["

8

Rationally attenuated genetically modified Brucella organisms

"] --> 33050["

9

Identifying suitable delivery systems for subunit vaccine candidates, killed bacteria and DNA vaccine candidates

"] 32993["

5

Development of a DNA vaccine for Brucellosis

• ASafety
• BDelivery Route
• CDelivery Platform
• DEfficacy in Challenge Model

"] --> 32970["

1

Brucella (B. abortus; B. melitensis; B. suis) vaccines

"] 33052["

10

Expression System

"] --> 33050["

9

Identifying suitable delivery systems for subunit vaccine candidates, killed bacteria and DNA vaccine candidates

"] 33061["

15

Host Responses to Natural Infection

"] --> 33055["

12

Establishing the identity of protective antigens of the various Brucella species

"] 33068["

17

Host Pathogen interaction in Brucellosis infection

• AEntry
• BReplication
• CPersistence/Clearance

"] --> 33065["

16

To identify protective mechanisms in Brucella-infected animals

• AAntibody Response
• BCell Mediated Immunity

"] 33068["

17

Host Pathogen interaction in Brucellosis infection

• AEntry
• BReplication
• CPersistence/Clearance

"] --> 33061["

15

Host Responses to Natural Infection

"] 33068["

17

Host Pathogen interaction in Brucellosis infection

• AEntry
• BReplication
• CPersistence/Clearance

"] --> 33059["

14

To establish the identity of the immunomodulatory factors and stealth mechanisms operating in Brucella infections

"] 33068["

17

Host Pathogen interaction in Brucellosis infection

• AEntry
• BReplication
• CPersistence/Clearance

"] --> 33057["

13

Identification of the Brucella virulence factors that contribute to disease pathology

"] 33059["

14

To establish the identity of the immunomodulatory factors and stealth mechanisms operating in Brucella infections

"] --> 33055["

12

Establishing the identity of protective antigens of the various Brucella species

"] 33065["

16

To identify protective mechanisms in Brucella-infected animals

• AAntibody Response
• BCell Mediated Immunity

"] --> 33055["

12

Establishing the identity of protective antigens of the various Brucella species

"] 33055["

12

Establishing the identity of protective antigens of the various Brucella species

"] --> 33050["

9

Identifying suitable delivery systems for subunit vaccine candidates, killed bacteria and DNA vaccine candidates

"] 33055["

12

Establishing the identity of protective antigens of the various Brucella species

"] --> 33052["

10

Expression System

"] 33055["

12

Establishing the identity of protective antigens of the various Brucella species

"] --> 33053["

11

Vector

"] 33057["

13

Identification of the Brucella virulence factors that contribute to disease pathology

"] --> 33055["

12

Establishing the identity of protective antigens of the various Brucella species

"] 32987["

4

Development of a killed/inactivated Brucella vaccine

• ASafety
• BDelivery Route
• CDelivery Platform
• DEfficacy in Challenge Model

"] --> 32970["

1

Brucella (B. abortus; B. melitensis; B. suis) vaccines

"] 32972["

2

Brucella (B. abortus; B. melitensis; B. suis) vaccines

• ASafety
• BDelivery Route
• CDelivery Platform
• DEfficacy in Challenge Model

"] --> 32970["

1

Brucella (B. abortus; B. melitensis; B. suis) vaccines

"] 33072["

18

Pathogen Genome

"] --> 33068["

17

Host Pathogen interaction in Brucellosis infection

• AEntry
• BReplication
• CPersistence/Clearance

"] 33072["

18

Pathogen Genome

"] --> 33065["

16

To identify protective mechanisms in Brucella-infected animals

• AAntibody Response
• BCell Mediated Immunity

"] 32982["

3

Development of a novel Brucellosis attenuated vaccine allowing DIVA

• ASafety
• BDelivery Route
• CDelivery Platform
• DEfficacy in Challenge Model

"] --> 32970["

1

Brucella (B. abortus; B. melitensis; B. suis) vaccines

"] 33032["

6

Development of a Brucella subunit vaccine

• ASafety
• BDelivery Route
• CDelivery Route
• DEfficacy in Challenge Model

"] --> 32970["

1

Brucella (B. abortus; B. melitensis; B. suis) vaccines

"] 33053["

11

Vector

"] --> 33042["

7

Development of a vectored Brucella vaccine

• 4Efficacy in Challenge Model
• ASafety
• BDelivery Route
• CDelivery Platform

"] 33042["

7

Development of a vectored Brucella vaccine

• 4Efficacy in Challenge Model
• ASafety
• BDelivery Route
• CDelivery Platform

"] --> 32970["

1

Brucella (B. abortus; B. melitensis; B. suis) vaccines

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