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Porcine Reproductive & Respiratory Syndrome roadmap:
Vaccines

Roadmap for development of a candidate vaccine for PRRSV

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2

Naturally attenuated candidates
  • ASafety
  • BDelivery route
  • CDelivery platform
  • DEfficacy in challenge model
"] --> 32959["

1

Vaccine
    "] 32962["

    3

    Rationally attenuated candidates
    • ASafety
    • BDelivery route
    • CDelivery platform
    • DEfficacy in challenge model
    "] --> 32959["

    1

    Vaccine
      "] 33002["

      4

      Inactivated vaccines
      • ASafety
      • BDelivery route
      • CDelivery platform
      • DEfficacy in challenge model
      "] --> 32959["

      1

      Vaccine
        "] 33007["

        5

        DNA/RNA vaccines
        • ASafety
        • BDelivery route
        • CDelivery platform
        • DEfficacy in challenge model
        "] --> 32959["

        1

        Vaccine
          "] 33016["

          6

          Subunit vaccines
          • ASafety
          • BDelivery route
          • CDelivery platform
          • DEfficacy in challenge model
          "] --> 32959["

          1

          Vaccine
            "] 33021["

            7

            Vectored vaccines
            • ASafety
            • BDelivery route
            • CDelivery platform
            • DEfficacy in challenge model
            "] --> 32959["

            1

            Vaccine
              "] 33026["

              8

              Attenuated organisms
                "] --> 32962["

                3

                Rationally attenuated candidates
                • ASafety
                • BDelivery route
                • CDelivery platform
                • DEfficacy in challenge model
                "] 33027["

                9

                Adjuvant
                  "] --> 33002["

                  4

                  Inactivated vaccines
                  • ASafety
                  • BDelivery route
                  • CDelivery platform
                  • DEfficacy in challenge model
                  "] 33027["

                  9

                  Adjuvant
                    "] --> 33007["

                    5

                    DNA/RNA vaccines
                    • ASafety
                    • BDelivery route
                    • CDelivery platform
                    • DEfficacy in challenge model
                    "] 33027["

                    9

                    Adjuvant
                      "] --> 33016["

                      6

                      Subunit vaccines
                      • ASafety
                      • BDelivery route
                      • CDelivery platform
                      • DEfficacy in challenge model
                      "] 33028["

                      10

                      Expression system
                        "] --> 33027["

                        9

                        Adjuvant
                          "] 33029["

                          11

                          Vector
                            "] --> 33021["

                            7

                            Vectored vaccines
                            • ASafety
                            • BDelivery route
                            • CDelivery platform
                            • DEfficacy in challenge model
                            "] 33036["

                            12

                            Identity of virulence factors
                              "] --> 33027["

                              9

                              Adjuvant
                                "] 33036["

                                12

                                Identity of virulence factors
                                  "] --> 33028["

                                  10

                                  Expression system
                                    "] 33036["

                                    12

                                    Identity of virulence factors
                                      "] --> 33029["

                                      11

                                      Vector
                                        "] 33041["

                                        13

                                        Identity of virulence factors
                                          "] --> 33026["

                                          8

                                          Attenuated organisms
                                            "] 33041["

                                            13

                                            Identity of virulence factors
                                              "] --> 33036["

                                              12

                                              Identity of virulence factors
                                                "] 33045["

                                                14

                                                Identity of immunomodulators
                                                  "] --> 33026["

                                                  8

                                                  Attenuated organisms
                                                    "] 33045["

                                                    14

                                                    Identity of immunomodulators
                                                      "] --> 33036["

                                                      12

                                                      Identity of virulence factors
                                                        "] 33049["

                                                        15

                                                        Host responses to natural infection
                                                          "] --> 33026["

                                                          8

                                                          Attenuated organisms
                                                            "] 33049["

                                                            15

                                                            Host responses to natural infection
                                                              "] --> 33036["

                                                              12

                                                              Identity of virulence factors
                                                                "] 33051["

                                                                16

                                                                Identity of mechanisms of protection
                                                                • AAntibody response
                                                                • BCell-mediated immunity
                                                                "] --> 33036["

                                                                12

                                                                Identity of virulence factors
                                                                  "] 33058["

                                                                  17

                                                                  Host-pathogen interactions
                                                                  • AEntry
                                                                  • BReplication
                                                                  • CPersistence/ clearance
                                                                  "] --> 33049["

                                                                  15

                                                                  Host responses to natural infection
                                                                    "] 33058["

                                                                    17

                                                                    Host-pathogen interactions
                                                                    • AEntry
                                                                    • BReplication
                                                                    • CPersistence/ clearance
                                                                    "] --> 33045["

                                                                    14

                                                                    Identity of immunomodulators
                                                                      "] 33058["

                                                                      17

                                                                      Host-pathogen interactions
                                                                      • AEntry
                                                                      • BReplication
                                                                      • CPersistence/ clearance
                                                                      "] --> 33041["

                                                                      13

                                                                      Identity of virulence factors
                                                                        "] 33058["

                                                                        17

                                                                        Host-pathogen interactions
                                                                        • AEntry
                                                                        • BReplication
                                                                        • CPersistence/ clearance
                                                                        "] --> 33051["

                                                                        16

                                                                        Identity of mechanisms of protection
                                                                        • AAntibody response
                                                                        • BCell-mediated immunity
                                                                        "] 33064["

                                                                        18

                                                                        Pathogen genome
                                                                          "] --> 33051["

                                                                          16

                                                                          Identity of mechanisms of protection
                                                                          • AAntibody response
                                                                          • BCell-mediated immunity
                                                                          "] 33064["

                                                                          18

                                                                          Pathogen genome
                                                                            "] --> 33058["

                                                                            17

                                                                            Host-pathogen interactions
                                                                            • AEntry
                                                                            • BReplication
                                                                            • CPersistence/ clearance
                                                                            "] linkStyle default stroke-width:1px,stroke:#3bcaf2
                                                                            Lead Summary Challenges and gap analysis
                                                                            1 Vaccine An improved multivalent PRRSV vaccine preventing disease, virus transmission and carrier state in vaccinated animals
                                                                            2D Efficacy in challenge model
                                                                            2C Delivery platform
                                                                            2B Delivery route
                                                                            2A Safety
                                                                            2 Naturally attenuated candidates
                                                                            3D Efficacy in challenge model
                                                                            3C Delivery platform
                                                                            3B Delivery route
                                                                            3A Safety
                                                                            3 Rationally attenuated candidates Development of an attenuated vaccine that doesn’t persist or is excreted
                                                                            4D Efficacy in challenge model
                                                                            4C Delivery platform
                                                                            4B Delivery route
                                                                            4A Safety
                                                                            4 Inactivated vaccines Development of cross protective/multivalent killed vaccine
                                                                            5D Efficacy in challenge model
                                                                            5C Delivery platform
                                                                            5B Delivery route
                                                                            5A Safety
                                                                            5 DNA/RNA vaccines
                                                                            6D Efficacy in challenge model
                                                                            6C Delivery platform
                                                                            6B Delivery route
                                                                            6A Safety
                                                                            6 Subunit vaccines Development of a cross protective/multivalent subunit vaccine
                                                                            7D Efficacy in challenge model
                                                                            7C Delivery platform
                                                                            7B Delivery route
                                                                            7A Safety
                                                                            7 Vectored vaccines Development of a cross protective/multivalent vectored PRRSV vaccine
                                                                            8 Attenuated organisms The generation of rationally attenuated genetically modified PRRSV
                                                                            9 Adjuvant Identifying suitable delivery systems for subunit and inactivated whole virus vaccine candidates
                                                                            10 Expression system
                                                                            11 Vector Identifying suitable vector for the expression/delivery of protective PRRSV Antigens
                                                                            12 Identity of virulence factors Identity of protective antigens
                                                                            13 Identity of virulence factors To establish the identity of the virulence factors in PRRSV that contribute to disease pathology
                                                                            14 Identity of immunomodulators To establish the identity of the immunomodulatory factors/stealth mechanisms in PRRSV
                                                                            15 Host responses to natural infection
                                                                            16B Cell-mediated immunity
                                                                            16A Antibody response
                                                                            16 Identity of mechanisms of protection To identify protective mechanisms in PRRSV infected animals
                                                                            17C Persistence/ clearance
                                                                            17B Replication
                                                                            17A Entry
                                                                            17 Host-pathogen interactions Host-pathogen interaction in PRRSV infection
                                                                            18 Pathogen genome