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Helminths (including anthelmintic resistance) roadmap:
Diagnostic Tests

Roadmap for development of diagnostic tests for helminths

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Validation
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    Diagnostic
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      Detection of host response
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        Validation
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          Expression system
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            Detection of host response
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              Stage specific antigens
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                Expression system
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                  Immune response"] --> 22185["

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                  Stage specific antigens
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                    Host pathogen interactions
                    • AEntry
                    • BReplication
                    • CPersistence clearance
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                    Immune response"] 22187["

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                    Host pathogen interactions
                    • AEntry
                    • BReplication
                    • CPersistence clearance
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                    Biomarker detection
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                      Antigen detection
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                        Antigen detection
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                            Genome characterisation
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                              Antigen detection
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                                            Direct detection identification
                                            • ASerotyping
                                            • BPhage typing
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                                            Validation
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                                                  Organism isolation media cell line
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                                                    Host pathogen interactions
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                                                    • BReplication
                                                    • CPersistence clearance
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                                                    Organism isolation media cell line
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                                                      Antigen detection
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                                                              Genome detection
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                                                                  Direct detection identification
                                                                  • ASerotyping
                                                                  • BPhage typing
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                                                                  Sample collection transport preparation
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                                                                    Organism isolation media cell line
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                                                                                Genome detection
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                                                                                    Direct detection identification
                                                                                    • ASerotyping
                                                                                    • BPhage typing
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                                                                                    Lead Summary Challenges and gap analysis
                                                                                    1 Diagnostic Improved diagnostics for nematode and trematode infections in ruminants
                                                                                    2 Validation Validation of diagnostic tests
                                                                                    3 Detection of host response Detection of host response
                                                                                    4 Expression system Development of expression systems for the large-scale cheap production of test antigens
                                                                                    5 Stage specific antigens Identification of stage-specific antigens that can be used in immune tests
                                                                                    6B Cell mediated immunity A knowledge of the cell-mediated immunity to infection with the various parasite species including its temporal nature
                                                                                    6A AB response A knowledge of the antibody response to infection with the various parasite species including its temporal nature
                                                                                    6 Immune response
                                                                                    7C Persistence clearance
                                                                                    7B Replication
                                                                                    7A Entry Host-pathogen interaction - entry and persistence
                                                                                    7 Host pathogen interactions
                                                                                    8 Antigen detection The detection of parasite specific antigens using antigen capture techniques incorporated in a diagnostic platform
                                                                                    9 Genome characterisation Genome characterisation for improved diagnosis
                                                                                    10 Genome detection Quantitative molecular tests for the detection of specific parasite species and anthelmintic resistance in practically useful diagnostic platforms
                                                                                    11B Phage typing
                                                                                    11A Serotyping
                                                                                    11 Direct detection identification Improved faecal egg counting methods for direct detection of helminth infections and anthelmintic resistance
                                                                                    12 Biomarker detection Isolation of helminth eggs for further analysis
                                                                                    13 Organism isolation media cell line Sample collection, preservation, transport and preparation of diagnostic samples for FEC/FECRT
                                                                                    14 Sample collection transport preparation