Foot and Mouth Disease roadmap:

Vaccines

Roadmap for the development of candidate vaccines for FMD

Download FMD Vaccine Roadmap

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2

Naturally attenuated candidates

ASafety
BDelivery route
CDelivery platform
DEfficacy in challenge model

"] --> 21367["

1

"] 21374["

3

Rationally attenuated candidates

ASafety
BDelivery route
CDelivery platform
DEfficacy in challenge model

"] --> 21367["

1

"] 21376["

4

Inactivated Vaccines

ASafety
BDelivery route
CDelivery platform
DEfficacy in challenge model

"] --> 21367["

1

"] 21380["

5

DNA/RNA vaccines

ASafety
BDelivery route
CDelivery platform
DEfficacy in challenge model

"] --> 21367["

1

"] 21386["

6

Subunit vaccines

ASafety
BDelivery route
CDelivery platform
DEfficacy in challenge model

"] --> 21367["

1

"] 21391["

7

Vectored vaccines

ASafety
BDelivery route
CDelivery platform
DEfficacy in challenge model

"] --> 21367["

1

"] 21396["

8

Attenuated organisms

"] --> 21374["

3

Rationally attenuated candidates

ASafety
BDelivery route
CDelivery platform
DEfficacy in challenge model

"] 21396["

8

Attenuated organisms

"] --> 21400["

9

"] 21400["

9

"] --> 21376["

4

Inactivated Vaccines

ASafety
BDelivery route
CDelivery platform
DEfficacy in challenge model

"] 21400["

9

"] --> 21380["

5

DNA/RNA vaccines

ASafety
BDelivery route
CDelivery platform
DEfficacy in challenge model

"] 21400["

9

"] --> 21386["

6

Subunit vaccines

ASafety
BDelivery route
CDelivery platform
DEfficacy in challenge model

"] 21401["

10

Expression system

"] --> 21400["

9

"] 21402["

11

"] --> 21391["

7

Vectored vaccines

ASafety
BDelivery route
CDelivery platform
DEfficacy in challenge model

"] 21403["

12

Identity of protective antigens

"] --> 21400["

9

"] 21403["

12

Identity of protective antigens

"] --> 21401["

10

Expression system

"] 21403["

12

Identity of protective antigens

"] --> 21402["

11

"] 21404["

13

Identity of virulence factors

"] --> 21396["

8

Attenuated organisms

"] 21404["

13

Identity of virulence factors

"] --> 21403["

12

Identity of protective antigens

"] 21405["

14

Identity of immunomodulators

"] --> 21396["

8

Attenuated organisms

"] 21405["

14

Identity of immunomodulators

"] --> 21403["

12

Identity of protective antigens

"] 21406["

15

Host responses to natural infection

"] --> 21396["

8

Attenuated organisms

"] 21406["

15

Host responses to natural infection

"] --> 21403["

12

Identity of protective antigens

"] 21406["

15

Host responses to natural infection

"] --> 21407["

16

Identity of mechanisms of protection

"] 21407["

16

Identity of mechanisms of protection

"] --> 21403["

12

Identity of protective antigens

"] 21408["

17

Host-pathogen interactions

"] --> 21404["

13

Identity of virulence factors

"] 21408["

17

Host-pathogen interactions

"] --> 21405["

14

Identity of immunomodulators

"] 21408["

17

Host-pathogen interactions

"] --> 21406["

15

Host responses to natural infection

"] 21408["

17

Host-pathogen interactions

"] --> 21412["

18

Challenge model

"] 21412["

18

Challenge model

"] --> 21368["

2

Naturally attenuated candidates

ASafety
BDelivery route
CDelivery platform
DEfficacy in challenge model

"] 21412["

18

Challenge model

"] --> 21374["

3

Rationally attenuated candidates

ASafety
BDelivery route
CDelivery platform
DEfficacy in challenge model

"] 21412["

18

Challenge model

"] --> 21376["

4

Inactivated Vaccines

ASafety
BDelivery route
CDelivery platform
DEfficacy in challenge model

"] 21412["

18

Challenge model

"] --> 21380["

5

DNA/RNA vaccines

ASafety
BDelivery route
CDelivery platform
DEfficacy in challenge model

"] 21412["

18

Challenge model

"] --> 21386["

6

Subunit vaccines

ASafety
BDelivery route
CDelivery platform
DEfficacy in challenge model

"] 21412["

18

Challenge model

"] --> 21391["

7

Vectored vaccines

ASafety
BDelivery route
CDelivery platform
DEfficacy in challenge model

"] 21415["

19

Pathogen genome

"] --> 21407["

16

Identity of mechanisms of protection

"] 21415["

19

Pathogen genome

"] --> 21408["

17

Host-pathogen interactions

"] linkStyle default stroke-width:1px,stroke:#3bcaf2

	Lead Summary	Challenges and gap analysis
2D	Efficacy in challenge model
2C	Delivery platform
2B	Delivery route
2A	Safety
2	Naturally attenuated candidates
1	Vaccine	Development of a genetically stable, effective, FMD DIVA vaccine inducing fast and long-lasting protection and preventing infection after vaccination, for all species, with one inoculation.
3D	Efficacy in challenge model
3C	Delivery platform
3B	Delivery route
3A	Safety
3	Rationally attenuated candidates	Rationally attenuated candidates
4D	Efficacy in challenge model
4C	Delivery platform
4B	Delivery route
4A	Safety
4	Inactivated Vaccines	Inactivated vaccines
5D	Efficacy in challenge model
5C	Delivery platform
5B	Delivery route
5A	Safety
5	DNA/RNA vaccines	A cross protective/multivalent DNA/RNA vaccine
6D	Efficacy in challenge model
6C	Delivery platform
6B	Delivery route
6A	Safety
6	Subunit vaccines	Development of a cross protective/multivalent species-specific subunit/peptide vaccine
7D	Efficacy in challenge model
7C	Delivery platform
7B	Delivery route
7A	Safety
7	Vectored vaccines	Development of cross-protective/multivalent species-specific vectored FMD Vaccines
8	Attenuated organisms	The generation of rationally attenuated genetically modified FMD virus
9	Adjuvant	Adjuvants
10	Expression system	Expression systems
11	Vector	Vector
12	Identity of protective antigens	Identity of protective antigens
13	Identity of virulence factors	Identity of the virulence factors
14	Identity of immunomodulators	Establishing the identity of the immunomodulatory factors/evasion mechanisms of FMDV
15	Host responses to natural infection	Host responses to natural infection
16B	Cell mediated immunity	Defining the role of cell-mediated immune responses in protection to FMDV
16A	Antibody response	Antibody response
16	Identity of mechanisms of protection	Identifying protective mechanisms in FMDV infected animals
17C	Persistence/clearance	Establishing the mechanisms of virus persistence/clearance from infected cells
17B	Replication	Establishing how FMDV replicates in the cell
17A	Entry	Defining entry mechanisms of FMDV into host cells
17	Host-pathogen interactions	Characterizing host-pathogen interaction
18	Challenge model	Challenge models for the different species
19	Pathogen genome	Pathogen genome