Bovine Tuberculosis (bTB) roadmap:

Diagnostic Tests

Roadmap for the development of diagnostic test for bTB

Download bTB-Diagnostics-Roadmap

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Stage specific antigens

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	Lead Summary	Challenges and gap analysis
1	Diagnostic	Diagnostic test development
2	Validation	Test validation
3	Detection of host response	Tools for detection of host response/organism at the individual level
4	Expression system
5	Stage specific antigens	Identification of Stage-specific markers
6B	Cell mediated immunity	Characterisation of the CMI responses during infection
6A	AB response	AB response during infection
6	Immune response	Characterisation of the immune response during infection
7C	Persistence clearance	Persistence/clearance : identification of signatures of clinical status at the individual level
7B	Replication
7A	Entry	HPI : role of innate cells (mostly macrophages and neutrophils ) in early clearance of M. bovis.
7	Host pathogen interactions	Characterisation of the host pathogen interaction
8	Antigen detection	Antigen identification
9	Genome characterisation	Genome Characterisation (WGS)
10	Genome detection	The detection of pathogen using molecular techniques
11B	Phage typing	Phage typing
11A	Serotyping
11	Direct detection identification	Direct detection
12	Biomarker detection	Biomarkers
13	Organism isolation media cell line
14	Sample collection transport preparation