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African Swine Fever roadmap:
Vaccines

Roadmap for the development of a candidate vaccine for ASF

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2

Naturally attenuated candidates
  • ASafety
  • BDelivery route
  • CDelivery platform
  • DEfficacy in challenge model
"] --> 22659["

1

Vaccine
    "] 22668["

    3

    Rationally attenuated candidates
    • ASafety
    • BDelivery route
    • CDelivery platform
    • DEfficacy in challenge model
    "] --> 22659["

    1

    Vaccine
      "] 22676["

      4

      Inactivated vaccines
      • ASafety
      • BDelivery route
      • CDelivery platform
      • DSafety
      "] --> 22659["

      1

      Vaccine
        "] 22678["

        5, 6

        DNA/RNA vaccines/Subunit vaccines"] --> 22659["

        1

        Vaccine
          "] 22693["

          7

          Vectored vaccines
          • ASafety
          • BDelivery route
          • CDelivery platform
          • DEfficacy in challenge model
          "] --> 22659["

          1

          Vaccine
            "] 22698["

            8

            Attenuated organisms
              "] --> 22668["

              3

              Rationally attenuated candidates
              • ASafety
              • BDelivery route
              • CDelivery platform
              • DEfficacy in challenge model
              "] 22698["

              8

              Attenuated organisms
                "] --> 22699["

                9

                Adjuvant
                  "] 22699["

                  9

                  Adjuvant
                    "] --> 22676["

                    4

                    Inactivated vaccines
                    • ASafety
                    • BDelivery route
                    • CDelivery platform
                    • DSafety
                    "] 22699["

                    9

                    Adjuvant
                      "] --> 22678["

                      5, 6

                      DNA/RNA vaccines/Subunit vaccines"] 22700["

                      10

                      Expression systems
                        "] --> 22699["

                        9

                        Adjuvant
                          "] 22701["

                          11

                          Vector
                            "] --> 22693["

                            7

                            Vectored vaccines
                            • ASafety
                            • BDelivery route
                            • CDelivery platform
                            • DEfficacy in challenge model
                            "] 22702["

                            12

                            Identity of protective antigens
                              "] --> 22699["

                              9

                              Adjuvant
                                "] 22702["

                                12

                                Identity of protective antigens
                                  "] --> 22700["

                                  10

                                  Expression systems
                                    "] 22702["

                                    12

                                    Identity of protective antigens
                                      "] --> 22701["

                                      11

                                      Vector
                                        "] 22703["

                                        13

                                        Identity of virulence factors
                                          "] --> 22698["

                                          8

                                          Attenuated organisms
                                            "] 22703["

                                            13

                                            Identity of virulence factors
                                              "] --> 22702["

                                              12

                                              Identity of protective antigens
                                                "] 22704["

                                                14

                                                Identity of immunomodulators
                                                  "] --> 22698["

                                                  8

                                                  Attenuated organisms
                                                    "] 22704["

                                                    14

                                                    Identity of immunomodulators
                                                      "] --> 22702["

                                                      12

                                                      Identity of protective antigens
                                                        "] 22705["

                                                        15

                                                        Host responses to natural infection
                                                          "] --> 22698["

                                                          8

                                                          Attenuated organisms
                                                            "] 22705["

                                                            15

                                                            Host responses to natural infection
                                                              "] --> 22702["

                                                              12

                                                              Identity of protective antigens
                                                                "] 22705["

                                                                15

                                                                Host responses to natural infection
                                                                  "] --> 22706["

                                                                  16

                                                                  Identity of mechanisms of protection"] 22706["

                                                                  16

                                                                  Identity of mechanisms of protection"] --> 22702["

                                                                  12

                                                                  Identity of protective antigens
                                                                    "] 22709["

                                                                    17

                                                                    Host pathogen interactions"] --> 22703["

                                                                    13

                                                                    Identity of virulence factors
                                                                      "] 22709["

                                                                      17

                                                                      Host pathogen interactions"] --> 22704["

                                                                      14

                                                                      Identity of immunomodulators
                                                                        "] 22709["

                                                                        17

                                                                        Host pathogen interactions"] --> 22705["

                                                                        15

                                                                        Host responses to natural infection
                                                                          "] 22709["

                                                                          17

                                                                          Host pathogen interactions"] --> 22713["

                                                                          18

                                                                          Challenge model
                                                                            "] 22713["

                                                                            18

                                                                            Challenge model
                                                                              "] --> 22663["

                                                                              2

                                                                              Naturally attenuated candidates
                                                                              • ASafety
                                                                              • BDelivery route
                                                                              • CDelivery platform
                                                                              • DEfficacy in challenge model
                                                                              "] 22713["

                                                                              18

                                                                              Challenge model
                                                                                "] --> 22668["

                                                                                3

                                                                                Rationally attenuated candidates
                                                                                • ASafety
                                                                                • BDelivery route
                                                                                • CDelivery platform
                                                                                • DEfficacy in challenge model
                                                                                "] 22713["

                                                                                18

                                                                                Challenge model
                                                                                  "] --> 22676["

                                                                                  4

                                                                                  Inactivated vaccines
                                                                                  • ASafety
                                                                                  • BDelivery route
                                                                                  • CDelivery platform
                                                                                  • DSafety
                                                                                  "] 22713["

                                                                                  18

                                                                                  Challenge model
                                                                                    "] --> 22678["

                                                                                    5, 6

                                                                                    DNA/RNA vaccines/Subunit vaccines"] 22713["

                                                                                    18

                                                                                    Challenge model
                                                                                      "] --> 22693["

                                                                                      7

                                                                                      Vectored vaccines
                                                                                      • ASafety
                                                                                      • BDelivery route
                                                                                      • CDelivery platform
                                                                                      • DEfficacy in challenge model
                                                                                      "] 22714["

                                                                                      19

                                                                                      Pathogen genome
                                                                                        "] --> 22706["

                                                                                        16

                                                                                        Identity of mechanisms of protection"] 22714["

                                                                                        19

                                                                                        Pathogen genome
                                                                                          "] --> 22709["

                                                                                          17

                                                                                          Host pathogen interactions"] linkStyle default stroke-width:1px,stroke:#3bcaf2
                                                                                          Lead Summary Challenges and gap analysis
                                                                                          1 Vaccine Vaccine
                                                                                          2D Efficacy in challenge model
                                                                                          2C Delivery platform
                                                                                          2B Delivery route
                                                                                          2A Safety
                                                                                          2 Naturally attenuated candidates Naturally attenuated candidates
                                                                                          3D Efficacy in challenge model
                                                                                          3C Delivery platform
                                                                                          3B Delivery route
                                                                                          3A Safety
                                                                                          3 Rationally attenuated candidates Rationally attenuated candidates
                                                                                          4D Safety
                                                                                          4C Delivery platform
                                                                                          4B Delivery route
                                                                                          4A Safety
                                                                                          4 Inactivated vaccines Inactivated vaccines
                                                                                          5, 6D Efficacy in challenge model
                                                                                          5, 6C Delivery platform
                                                                                          5, 6B Delivery route Delivery route
                                                                                          5, 6A Safety
                                                                                          5, 6 DNA/RNA vaccines/Subunit vaccines DNA/RNA vaccines/Subunit vaccines
                                                                                          7D Efficacy in challenge model
                                                                                          7C Delivery platform
                                                                                          7B Delivery route
                                                                                          7A Safety
                                                                                          7 Vectored vaccines Vectored vaccines
                                                                                          8 Attenuated organisms Attenuated organisms
                                                                                          9 Adjuvant Adjuvant
                                                                                          10 Expression systems
                                                                                          11 Vector Vector
                                                                                          12 Identity of protective antigens Identity of protective antigens
                                                                                          13 Identity of virulence factors Identity of virulence factors
                                                                                          14 Identity of immunomodulators Identity of immunomodulators
                                                                                          15 Host responses to natural infection Host responses to natural infection
                                                                                          16B Cell-mediated immunity Cell-mediated immunity
                                                                                          16A Antibody response Antibody response
                                                                                          16 Identity of mechanisms of protection Identity of mechanisms of protection
                                                                                          17C Persistence/clearance Persistence/clearance
                                                                                          17B Replication Replication
                                                                                          17A Entry Entry
                                                                                          17 Host pathogen interactions Host pathogen interactions
                                                                                          18 Challenge model
                                                                                          19 Pathogen genome Pathogen genome